Hyperlane is the platform for developers building the interchain universe. It provides an on-chain API for sending information between blockchains. Developers can use Hyperlane as an API to easily and securely communicate between blockchains, or they can utilize the Hyperlane SDK and tooling to quickly build interchain applications.

LayerZero is an Omnichain Interoperability Protocol designed for lightweight message passing across chains. It provides authentic and guaranteed message delivery with configurable trustlessness, implemented as a set of gas-efficient, non-upgradable smart contracts.

Wormhole is a decentralized, universal message-passing protocol that enables developers and users of cross chain applications to leverage the advantages of multiple ecosystems.

ZetaChain is the foundational, public blockchain that enables omnichain, generic smart contracts, and messaging between any blockchain. ZetaChain envisions and supports a truly fluid, multi-chain crypto ecosystem. These "omnichain" smart contracts can send data and value between connected blockchains, including Ethereum, Polygon, Binance Smart Chain, and eventually, non-smart chains such as Bitcoin and Dogecoin. ZetaChain is built on Cosmos SDK and Tendermint Consensus.

exSat is a Docking Layer that was built to bridge the gap between Bitcoin’s native layer and a multitude of Layer 2 scaling solutions for the Bitcoin ecosystem. By facilitating direct queries of BTC and ecosystem token balances, exSat enables a seamless flow of assets and information across different networks and Bitcoin Layer 2 scaling solutions.

Axelar is a decentralized cross-chain communication network, aiming to level-up interoperability in Web3 by connecting heterogeneous blockchains and enabling asset mobility and program composability in an optimized way for both builders and end-users. The two layers of Axelar are the network and the API above it. At the core of Axelar is a permissionless overlay network that provides Turing-complete cross-chain communication through proof-of-stake and permissionless protocols. On top of the network are APIs and protocols, an application-development layer that developers use to compose across any number of chains. Once integrated, all new interconnected blockchains become interoperable with the application, resulting in limitless network effects.

Omni is the Ethereum interoperability layer enables developers to program global applications that span Ethereum’s entire rollup ecosystem. When developing applications, developers won't have to be restricted to a single rollup or execution environment anymore; they will be able to build applications that exist everywhere in Ethereum's ecosystem, accessing all users and capital simultaneously. Omni was formerly known as Rift Finance, the DeFi protocol that provides financial services for Web3 projects.

deBridge is a secure interoperability layer for Web3 that enables decentralized transfers of arbitrary messages and value between various blockchains. Validation of cross-chain transactions is performed by a network of independent validators, elected by and working for deBridge governance. These validators maintain the blockchain infrastructure and each run a deBridge node to sign all transactions that pass through deBridge smart contracts in different blockchains.

Zeus Network serves as a crucial permissionless layer, harnessing the formidable strengths of both Solana and Bitcoin, that enables dynamic, secure composability, creating a decentralized ecosystem for seamless user engagement and liquidity interaction. Zeus Network is NOT a bridge. Because liquidity providers on each chain do not receive liquidity back on the other chain, the assets provided on each chain are protected by their respective protocols.

Socket 2.0 is the first Chain Abstraction Protocol for Web3. It is a modular, extensible, and composable protocol that enables chain-agnostic applications. Socket abstracts away the underlying complexity of chains, allowing users to interact with applications without having to worry about the underlying chain.

Everclear is the new foundation of the chain abstraction stack, integrating with intent protocols, solver networks, modular blockchains, and dApps to enable the most efficient transaction settlement at the best possible price. Everclear coordinates the global settlement of liquidity between chains, solving fragmentation for modular blockchains.

oooo is a modular omnichain interoperability protocol supporting the Bitcoin ecosystem. Its modular communication protocol architecture ensures the integrity and reliability of data and transactions within the system. This approach resolves blockchain isolation and liquidity fragmentation, boosting capital efficiency and utilization, and ultimately improving the user experience. oooo is pioneering the next evolution in blockchain interoperability by introducing AI Omninet — an intelligent protocol that transforms cross-chain intents into seamless operations.

MultichainZ is a cross-chain interoperability protocol acts as a unifying layer, allowing different blockchain networks to seamlessly interact, communicate, and transact with one another.

IBC is an open-source protocol developed by a global community, funded by the Interchain Foundation. It aims to enhance cross-chain communication's robustness, security, and functionality, maintained and evolved by various organizations.

TeleSwap is a trustless and universal interoperability protocol that provides developers with an infrastructure to build cross-chain applications. With it, users can transfer any data, such as messages, contract calls, tokens, or NFTs, between blockchains.

Analog is a completely decentralized layer-0 platform for communicating validated event data with the Proof-of-Time consensus mechanism. At the core of the platform are tesseracts and time nodes that can privately fetch and confirm event data from sovereign chains, allowing different ecosystems to speak the same language. Analog aims to bring trustless, omnichain interoperability, enabling developers to build their applications via a universal protocol and an API. Additionally, Analog is unveiling a novel, superfast PoT protocol that creates verifiable event data on the Timechain, allowing DApp developers to build next-generation event-based applications.

LI.FI is a bridge aggregation protocol with DEX connectivity and cross-chain data messaging capabilities. All of these functions will be made available on an API/Contract level, and as a widget for other developers to plug directly into their products.

Toposis an interoperability protocol that enables public and private blockchains to communicate with each other. Zero-knowledge proofs allow blockchains to prove the validity of their state transitions without revealing private information, such as account addresses and account balances.

Polymer is the interoperability uub of Ethereum. Polymer provides IBC execution to connected Layer 2s without requiring a native IBC integration, enabling new L2s to permissionlessly connect to the IBC network. Polymer enhances composability between Ethereum rollups while leveraging IBC’s expanding network of applications.

MAP Protocol is the interoperable layer for the Bitcoin network, built upon ZK light-clients. It is the gateway for Bitcoin ecosystem developers and users and the way for different Bitcoin L2s as well as the Bitcoin ecosystem to become interoperable with EVM & non-EVM ecosystems.

Satoshi Protocol is a cross-chain messaging bridge built on BTC-Light-Node and Chain Abstraction technology.

Celer is a blockchain interoperability protocol that provides a one-click user experience for accessing tokens, DeFi, GameFi, NFTs, governance, and more across multiple chains. Developers can use the Celer Inter-chain Message SDK to build inter-chain-native dApps, enabling efficient liquidity utilization, coherent application logic, and shared states.

GVNR is a General Message Passing Protocol that enables seamless connection between every compatible chain, peer-to-peer. GVNR is built for all users and especially AI Agents. GVNR enables permissionless universal control of all chains and all assets. GVNR can be deployed to any permissionless or permissioned blockchain, and will be self-deployable by chains, foundations or enterprises that wish to access the widest possible liquidity.

Stripchain is a cross-chain interoperability protocol allows developers to create commands called intents to perform actions like transferring data between blockchains. Based on a system called stripVM, it will enable applications to communicate and coordinate with different protocols.

Glacis is a protocol that empowers developers to simplify, secure, and manage their cross-chain applications. Developers are shifting from single chain to multichain deployments to reach as many users as possible. By leveraging Glacis to aggregate cross-chain General Messaging Passing protocols (GMPs) such as Axelar, Wormhole, and LayerZero — commonly known as bridges — developers gain the ability to define routing and security logic for their cross-chain applications.

MailZero is a platform that enables Web2 to Web3 interoperability for Stamp2Earn.The underlying layer that MailZero plans to develop hopes to achieve the vision of true interoperability by connecting all chains, whether they are part of the EVM ecosystem, IBC ecosystem, or other ecosystems. Users will no longer be constrained by whether mainstream protocols support certain chains.

Electron Labs is an universal ZK-proof aggregation layer for Ethereum. It uses light clients and zero-knowledge proofs to maintain decentralization. Electron uses UPA underneath to aggregate proofs from multiple source into a single superproof, thus amortizing the cost per use case.

Vizing is an omni interoperability environment built on advanced zk technology, provides a faster, more affordable, and safer Ethereum ecosystem roaming experience. Meanwhile, Vizing is a permissionless decentralized network that provides all DApps with the ability to interact with multiple chains by integrating with Vizing.

PicWe is a decentralized, trustless, omni-chain liquidity infrastructure enabling seamless, cost-efficient trading across multiple blockchains and liquidity pools.

Sygma is a cross-consensus interoperability protocol, enabling general message passing, asset transfers, non-fungible tokens, and decentralized finance. Evolved from the humble beginnings of ChainBridge, it provides native interoperability between the Ethereum and Polkadot ecosystems.